Helmut Fuchs Selected Research

Phospholipase C gamma

8/2009	Characterization of phospholipase C gamma enzymes with gain-of-function mutations.
4/2005	Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry.

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Helmut Fuchs Research Topics

Disease

11	Inflammation (Inflammations) 01/2018 - 04/2005
7	Type 2 Diabetes Mellitus (MODY) 01/2021 - 01/2013
6	Obesity 01/2020 - 05/2004
6	Neoplasms (Cancer) 01/2020 - 01/2013
5	Body Weight (Weight, Body) 01/2018 - 03/2007
5	Hearing Loss (Hearing Impairment) 11/2017 - 10/2008
4	Cataract (Cataracts) 01/2021 - 08/2002
4	Infections 01/2021 - 09/2005
4	Insulin Resistance 01/2018 - 01/2013
4	Asthma (Bronchial Asthma) 01/2017 - 09/2011
4	Juvenile gout 01/2014 - 11/2009
3	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 12/2015
3	Kidney Diseases (Kidney Disease) 01/2022 - 01/2016
3	Microphthalmos 11/2019 - 05/2004
3	Cardiomyopathies (Cardiomyopathy) 01/2019 - 04/2015
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2019 - 01/2013
3	Cardiovascular Diseases (Cardiovascular Disease) 10/2018 - 10/2016
3	Deafness (Deaf Mutism) 12/2015 - 10/2008
2	Atrophy 01/2021 - 10/2013
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 03/2008
2	Pain (Aches) 01/2019 - 10/2011
2	Hypertension (High Blood Pressure) 10/2018 - 12/2016
2	Arthritis (Polyarthritis) 01/2018 - 05/2011
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2018 - 01/2016
2	Fatty Liver 01/2017 - 10/2016
2	Hypoxia (Hypoxemia) 01/2017 - 08/2012
2	Non-alcoholic Fatty Liver Disease 01/2017 - 01/2013
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2017 - 04/2014
2	Heart Failure 12/2016 - 04/2015
2	Hyperlipidemias (Hyperlipidemia) 10/2016 - 01/2016
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 03/2016 - 02/2016
2	Hyperplasia 01/2016 - 10/2013
2	Male Infertility (Male Sterility) 01/2016 - 05/2011
2	Bartter Syndrome (Syndrome, Bartter) 08/2014 - 06/2010
2	Fibrosis (Cirrhosis) 10/2013 - 12/2012
2	Osteogenesis Imperfecta (Lobstein Disease) 08/2012 - 02/2008
2	Metabolic Bone Diseases (Osteopenia) 08/2012 - 06/2010
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2022
1	Nervous System Diseases (Neurological Disorders) 10/2021
1	Vision Disorders (Hemeralopia) 10/2021
1	Fetal Growth Retardation (Intrauterine Growth Retardation) 01/2021
1	Gynecomastia 10/2020
1	Hemorrhage 10/2020
1	Hepatocellular Carcinoma (Hepatoma) 01/2020
1	Methylmalonic acidemia 01/2020
1	Gliosis 01/2020

Drug/Important Bio-Agent (IBA)

13	Proteins (Proteins, Gene)FDA Link 01/2020 - 05/2004
7	Ethylnitrosourea (N-Ethyl-N-nitrosourea)IBA 01/2018 - 04/2005
5	Retinaldehyde (Retinal)IBA 01/2021 - 02/2004
5	Urea (Carbamide)FDA LinkGeneric 08/2017 - 11/2009
4	IronIBA 10/2021 - 01/2014
4	RNA (Ribonucleic Acid)IBA 01/2020 - 09/2014
4	Insulin (Novolin)FDA Link 01/2020 - 01/2013
4	Glucose (Dextrose)FDA LinkGeneric 01/2017 - 01/2013
4	Transcription Factors (Transcription Factor)IBA 01/2017 - 01/2009
4	LipidsIBA 01/2017 - 11/2009
4	UromodulinIBA 01/2014 - 11/2009
3	MethyltransferasesIBA 01/2020 - 09/2014
3	Hormones (Hormone)IBA 01/2019 - 10/2014
3	CytokinesIBA 10/2013 - 09/2005
2	Alkaline PhosphataseIBA 01/2022 - 08/2013
2	Mitochondrial DNA (mtDNA)IBA 01/2022 - 12/2015
2	Estrogens (Estrogen)FDA Link 10/2020 - 02/2016
2	Transfer RNA (tRNA)IBA 01/2020 - 01/2019
2	Messenger RNA (mRNA)IBA 11/2019 - 01/2018
2	EnzymesIBA 01/2019 - 09/2009
2	Streptozocin (Streptozotocin)FDA Link 01/2018 - 01/2016
2	Biomarkers (Surrogate Marker)IBA 01/2018 - 08/2012
2	BezafibrateIBA 01/2017 - 01/2016
2	Erythropoietin FDA Link 01/2017 - 01/2009
2	Pharmaceutical PreparationsIBA 01/2017 - 09/2010
2	SaltsIBA 12/2016 - 06/2010
2	Thyroid HormonesIBA 10/2016 - 01/2013
2	CalcineurinIBA 08/2015 - 04/2015
2	MicroRNAs (MicroRNA)IBA 05/2015 - 05/2009
2	Crystallins (Crystallin)IBA 11/2014 - 08/2002
2	Member 1 Solute Carrier Family 12IBA 08/2014 - 06/2010
2	DNA-Binding Proteins (DNA Binding Protein)IBA 04/2014 - 10/2011
2	Uric Acid (Urate)IBA 10/2013 - 11/2009
2	Interleukin-6 (Interleukin 6)IBA 10/2013 - 01/2009
2	ATP-Binding Cassette Transporters (ABC Transporters)IBA 08/2013 - 12/2012
2	CollagenIBA 08/2013 - 08/2012
2	Phospholipases (Phospholipase)IBA 05/2011 - 04/2005
2	Phospholipase C gammaIBA 08/2009 - 04/2005
1	Exonucleases (3' 5' Exonuclease)IBA 01/2022
1	exodeoxyribonuclease IIBA 01/2022
1	PotassiumIBA 01/2022
1	Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)IBA 12/2021
1	Sucrose (Saccharose)IBA 01/2021
1	CorticosteroneIBA 01/2021
1	Poly I-CIBA 01/2021
1	AndrogensIBA 10/2020
1	Thromboplastin (Tissue Factor)IBA 10/2020
1	DisulfidesIBA 10/2020
1	Uncoupling Protein 1IBA 01/2020
1	Methylmalonyl-CoA MutaseIBA 01/2020
1	Transferrin Receptors (Transferrin Receptor)IBA 01/2020
1	Ferritins (Ferritin)IBA 01/2020

Therapy/Procedure

4	Therapeutics 01/2016 - 09/2010
2	Lenses 01/2022 - 01/2021